Association between respiratory syncytial virus associated acute lower respiratory infection in early life and subsequent recurrent wheeze and asthma in later childhood.

Ting Shi, Yujing Ooi, Ei Mon Zaw, Natasa Utjesanovic, Harry Campbell, Steve Cunningham, Louis Bont, Harish Nair, RESCEU Investigators.

Abstract

Background
Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years.

Methods
We estimated the strength of association by 3 control groups and 3 follow-up age groups, with data from studies published between January 1995 and May 2018. We also estimated associations by diagnostic criteria, age at infection, and high-risk population.

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