Respiratory Syncytial Virus Associated Acute Lower Respiratory Infections in Children with Bronchopulmonary dysplasia: Systematic Review and Meta-analysis.

Pa Saidou Chaw, Lei Hua, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, et al.

Respiratory syncytial virus (RSV) is among the most important causes of acute lower respiratory tract infection (ALRI) in young children. We assessed the severity of RSV-ALRI in children less than 5 years old with bronchopulmonary dysplasia (BPD).

We searched for studies using EMBASE, Global Health, and MEDLINE. We assessed hospitalization risk, intensive care unit (ICU) admission, need for oxygen supplementation and mechanical ventilation, and in-hospital case fatality (hCFR) among children with BPD compared with those without (non-BPD). We compared the (1) length of hospital stay (LOS) and (2) duration of oxygen supplementation and mechanical ventilation between the groups.

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