RESCEU publications

RESCEU Publications

RESCEU publications

54

J G Wildenbeest, M-N Billard, Roy P Zuurbier, K Korsten, A CLangedijk, P Mvan de Ven, M D Snape, S BDrysdale,  A J Pollard FMedSci, H Robinson,T Heikkinen, S Cunningham, T O’Neill, B Rizkalla, A Dacosta-Urbieta, F Martinón-Torres, M Avan Houten, L J Bont, RESCEU Investigators The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study Lancet Respir Med, 10 Nov 2022

https://doi.org/10.1016/S2213-2600(22)00414-3
53

Shanshan Zhang, Pia Wahi-Singh, Bhanu Wahi-Singh, Alison Chisholm, Polly Keeling, Harish Nair, RESCEU Investigators Costs of management of acute respiratory infections in older adults: A systematic review and meta-analysis J Glob Health, 08 Nov 2022

10.7189/jogh.12.04096
52

Roy P Zuurbier, Koos Korsten, Theo J M Verheij, Chris Butler, Niels Adriaenssens, Samuel Coenen, Olivier Gruselle, Valerie Vantomme, Marlies A van Houten, Louis J Bont, Joanne G Wildenbeest, REspiratory Syncytial Virus Consortium in EUrope (RESCEU) Investigators Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults JID, 04 Feb 2022

10.1093/infdis/jiab600
51

Maarten van Wijhe, Caroline Klint Johannesen, Lone Simonsen, Inger Merete Jørgensen, the RESCEU Investigators , Thea K Fischer A Retrospective Cohort Study on Infant Respiratory Tract Infection Hospitalizations and Recurrent Wheeze and Asthma Risk: Impact of Respiratory Syncytial Virus JID, 15 April 2022

10.1093/infdis/jiac141
50

Guy Berbers, Liesbeth Mollema, Fiona van der Klis, Gerco den Hartog, Rutger Schepp Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years JID, 15 July 2021

10.1093/infdis/jiaa483
49

Michiel van Boven, Anne C Teirlinck, Adam Meijer, Mariëtte Hooiveld, Christiaan H van Dorp, Rachel M Reeves, Harry Campbell, Wim van der Hoek, RESCEU Investigators Estimating Transmission Parameters for Respiratory Syncytial Virus and Predicting the Impact of Maternal and Pediatric Vaccination JID, 1 Nov 2020

10.1093/infdis/jiaa424
48

Madelief Mollers, Céline Barnadas, Eeva K Broberg, Pasi Penttinen, European Influenza Surveillance Network, Anne C Teirlinck, Thea K Fischer Current practices for respiratory syncytial virus surveillance across the EU/EEA Member States, 2017 Euro Surveill. 2019

10.2807/1560-7917.ES.2019.24.40.1900157
47

Xin Wang, You Li, Ting Shi, Yiming Ma, Bhanu Wahi-Singh, Richard D Riley, Harish Nair Global Disease Burden of Respiratory Syncytial Virus in Preterm Children in 2019: A Systematic Review and Individual Participant Data Meta-Analysis Protocol JID, 27 Apr 2022

10.1093/infdis/jiac078
46

van Wijhe M, Johannesen CK, Simonsen L, Jørgensen IM; RESCEU Investigators, Fischer TK. A Retrospective Cohort Study on Infant Respiratory Tract Infection Hospitalizations and Recurrent Wheeze and Asthma Risk: Impact of Respiratory Syncytial Virus JID, Apr 15 2022

10.1093/infdis/jiac141
45

Li X, Bilcke J, Vázquez Fernández L, Bont L, Willem L, Wisløff T, Jit M, Beutels P; REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators. Cost-effectiveness of Respiratory Syncytial Virus Disease Prevention Strategies: Maternal Vaccine Versus Seasonal or Year-Round Monoclonal Antibody Program in Norwegian Children JID, Mar 16 2022

10.1093/infdis/jiac064
44

McGinley JP, Lin GL, Öner D, Golubchik T, O’Connor D, Snape MD, Gruselle O, Langedijk AC, Wildenbeest J, Openshaw P, Nair H, Aerssens J, Bont L, Martinón-Torres F, Drysdale SB, Pollard AJ; RESCEU Investigators. Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection JID, Jul 28 2022

10.1093/infdis/jiac163
43

Billard MN, Wildenbeest J, Bont LJ, Nair H, McCracken JP, Oude Rengerink K; RESCEU Investigators. Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials J Clin Epidemiol, Feb 26 2022

10.1016/j.jclinepi.2022.02.003
42

Johannesen CK, van Wijhe M, Tong S, Fernández LV, Heikkinen T, van Boven M, Wang X, Bøås H, Li Y, Campbell H, Paget J, Stona L, Teirlinck A, Lehtonen T, Nohynek H, Bangert M, Fischer TK; RESCEU Investigators. Age-Specific Estimates of Respiratory Syncytial Virus-Associated Hospitalizations in 6 European Countries: A Time Series Analysis JID, Jun 24 2022

10.1093/infdis/jiac150
41

Reeves RM, van Wijhe M, Lehtonen T, Stona L, Teirlinck AC, Vazquez Fernandez L, Li Y, Osei-Yeboah R, Fischer TK, Heikkinen T, van Boven M, Bøås H, Donà D, Barbieri E, Campbell H; RESCEU Investigators. A Systematic Review of European Clinical Practice Guidelines for Respiratory Syncytial Virus Prophylaxis JID, Mar 25 2022

10.1093/infdis/jiac059
40

Mao Z, Li X, Korsten K, Bont L, Butler C, Wildenbeest J, Coenen S, Hens N, Bilcke J, Beutels P; RESCEU Investigators. Economic Burden and Health-Related Quality of Life of Respiratory Syncytial Virus and Influenza Infection in European Community-Dwelling Older Adults JID, Aug 12 2022

10.1093/infdis/jiac069
39

You Li, Xin Wang, Diana M. Blau, Mauricio T. Caballero, Daniel R. Feikin, Cristopher J. Gill, Shabir A Madhi, Saad B. Omer, Eric A. F. Simoes, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis The Lancet Journal, May 19 2022

https://doi.org/10.1016/S0140-6736(22)00478-0
38

Nicole D Derksen-Lazet, Corline E J Parmentier, Joanne G Wildenbeest, Louis J Bont, RESCEU Investigators Patient Involvement in RSV Research: Towards Patients Setting the Research Agenda The Journal of Infectious Diseases, 2022;, jiac110

https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac110/6575694?login=true
37

Thomas C Williams, Mark D Lyttle, Steve Cunningham, Ian Sinha, Olivia V Swann, Abigail Maxwell-Hodkinson, Robin Marlow, Damian Roland, Paediatric Emergency Research in the UK and Ireland (PERUKI) Study Pre-protocol for “BronchStart – The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study” Wellcome Open Res. 2022[21 Jan 2022];6:120

https://wellcomeopenresearch.org/articles/6-120/v2
36

Wang X, Li Y, Vazquez Fernandez L, Teirlinck AC, Lehtonen T, van Wijhe M, Stona L, Bangert M, Reeves RM, Bøås H, van Boven M, Heikkinen T, Klint Johannesen C, Baraldi E, Donà D, Tong S, Campbell H Respiratory Syncytial Virus–Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries JID. 2022[12 Jan 2022];jiab560

https://doi.org/10.1093/infdis/jiab560
35

Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C Butler, Jean-Yves Pirçon, Theo J M Verheij, Louis J Bont, Joanne G Wildenbeest, RESCEU Investigators Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe – the RESCEU Study JID. 2021[15 Dec 2021];jiab519.

https://doi.org/10.1093/infdis/jiab519
34

Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C Butler, Theo J M Verheij, Louis J Bont, Joanne G Wildenbeest, RESCEU Investigators. World Health Organization Influenza-Like Illness Underestimates the Burden of Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults JID. 2021[14 Dec 2021];jiab452.

https://doi.org/10.1093/infdis/jiab452
33

Teirlinck AC, Broberg EK, Stuwitz Berg A, Campbell H, Reeves RM, Carnahan A, et al. Recommendations for respiratory syncytial virus surveillance at the national level Eur Respir J. 2021[1 Oct 2021];58(3):2003766

https://erj.ersjournals.com/content/58/3/2003766
32

Joseph McGinley, Ryan Thwaites, Will Brebner, Lewis Greenan-Barrett, Jeroen Aerssens, Deniz Öner, Louis Bont, Joanne Wildenbeest, Federico Martinón-Torres, Harish Nair, Andrew J Pollard, Peter Openshaw, Simon Drysdale, RESCEU Investigators A Systematic Review and Meta-analysis of Animal Studies Investigating the Relationship Between Serum Antibody, T Lymphocytes, and Respiratory Syncytial Virus Disease JID. 2021[15 Sep 2021];jiab370.

https://doi.org/10.1093/infdis/jiab370
31

Wang X, Li Y, Nair H, Campbell H; RESCEU Investigators Time-Varying Association Between Severe Respiratory Syncytial Virus Infections and Subsequent Severe Asthma and Wheeze and Influences of Age at the Infection JID. 2021[15 Sep 2021];jiab308.

https://doi.org/10.1093/infdis/jiab308
30

Shi T, Vennard S, Jasiewicz F, Brogden R, Nair H; RESCEU Investigators Disease Burden Estimates of Respiratory Syncytial Virus related Acute Respiratory Infections in Adults With Comorbidity: A Systematic Review and Meta-Analysis JID. 2021[15 Sep 2021];jiab040.

https://doi.org/10.1093/infdis/jiab040
29

Gu-Lung Lin, Simon B Drysdale, Matthew D Snape, Daniel O’Connor, Anthony Brown, George MacIntyre-Cockett, Esther Mellado-Gomez, Mariateresa de Cesare, David Bonsall, M Azim Ansari, Deniz Öner, Jeroen Aerssens, Christopher Butler, Louis Bont, Peter Openshaw, Federico Martinón-Torres, Harish Nair, Rory Bowden, RESCEU Investigators; Tanya Golubchik, Andrew J Pollard Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus Nat Commun. 2021[26 Aug 2021];12(1):5125.

https://www.nature.com/articles/s41467-021-25265-4
28

Rosalie S Linssen, Anne C Teirlinck, Michiel van Boven, Dominique Biarent, Luca Stona, Angela Amigoni, Rosanna I Comoretto, Stephane Leteurtre, Amélie Bruandet, Gunnar K Bentsen, Inger Marie Drage, Xin Wang, Harry Campbell, Job B M van Woensel, Louis Bont, Reinout A Bem Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study J Crit Care. [22 Jul 2021];S0883-9441(21)00150-7.

https://doi.org/10.1016/j.jcrc.2021.07.009
27

Rosalie S Linssen, Reinout A Bem, Berber Kapitein, Katrien Oude Rengerink, Marieke H Otten, Bibiche den Hollander, Louis Bont, Job B M van Woensel Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units Eur J Pediatr. 2021[23 Apr 2021];s00431-021-04079-y

https://link.springer.com/article/10.1007/s00431-021-04079-y
26

Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study ERJ. 2021[1 Apr 2021];13993003.02688-2020

https://erj.ersjournals.com/content/57/4/2002688
25

F Zeevat, J Luttjeboer, J H J Paulissen, J van der Schans, P Beutels, C Boersma, M J Postma, RESCEU Investigators Exploratory Analysis of the Economically Justifiable Price of a Hypothetical RSV Vaccine for Older Adults in the Netherlands and the United Kingdom JID. 2021[1 Apr 2021];jiab118.

https://doi.org/10.1093/infdis/jiab118
24

Ting Shi, Sophie Vennard, Sara Mahdy, Harish Nair Risk factors for RSV associated acute lower respiratory infection poor outcome and mortality in young children: A systematic review and meta-analysis JID. 2021[12 Feb 2021]; jiaa751.

https://doi.org/10.1093/infdis/jiaa751
23

Rutger M. Schepp, Cornelis A. M. de Haan, Deidre Wilkins, Hans Layman, Barney S. Graham, Mark T. Esser, Guy A. M. Berbers Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins mSphere. 2019[24 Apr 2019];4(2):e00236-19.

https://doi.org/10.1128/msphere.00236-19
22

Gu-Lung Lin, Joseph P. McGinley, Simon B. Drysdale, Andrew J. Pollard Epidemiology and Immune Pathogenesis of Viral Sepsis Front Immunol. 2018[27 Sep 2018];9:2147.

https://doi.org/10.3389/fimmu.2018.02147
21

Li X, Willem L, Antillon M, Bilcke J, Jit M, Beutels P. Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries. BMC Med. 2020[6 Apr 2020];18(1):82

https://doi.org/10.1186/s12916-020-01537-6
20

Lin GL, Golubchik T, Drysdale S, O’Connor D, Jefferies K, Brown A, de Cesare M, Bonsall D, Ansari MA, Aerssens J, Bont L, Openshaw P, Martinón-Torres F, Bowden R, Pollard AJ; RESCEU Investigators. Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants JID. 2020[7 Oct 2020];222(Supplement_7):S666-S671.

https://doi.org/10.1093/infdis/jiaa448
19

Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, Moore DP, Nunes M, Rath B, Campbell H, Nair H; RSV Global Epidemiology Network; RESCEU investigators. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis Lancet Glob Health. 2019 [Aug 2019];7(8):e1031-e1045.

https://doi.org/10.1016/s2214-109x(19)30264-5
18

Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators. Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study Eur Respir J. 2020 [15 Oct 2020];2002688

https://doi.org/10.1183/13993003.02688-2020
17

Rachel M Reeves, Maarten van Wijhe, Sabine Tong, Toni Lehtonen, Luca Stona, Anne C Teirlinck, Liliana Vazquez Fernandez, You Li, Carlo Giaquinto, Thea Kølsen Fischer, Clarisse Demont, Terho Heikkinen, Irene Speltra, Michiel van Boven, Håkon Bøås, Harry Campbell, RESCEU Investigators RSV-associated hospital admissions in children younger than five years in seven European countries using routinely collected datasets JID. 2020[20 August 2020];jiaa360

https://doi.org/10.1093/infdis/jiaa360
16

Alexandria Chung, Rachel M Reeves, Harish Nair, Harry Campbell, RESCEU investigators Hospital admission trends for bronchiolitis in Scotland, 2001-2016: a national retrospective observational study JID. 2020 [14 August 2020];jiaa323.

https://doi.org/10.1093/infdis/jiaa323
15

Michiel van Boven, Anne C Teirlinck, Adam Meijer, Mariëtte Hooiveld, Christiaan H van Dorp, Rachel M Reeves, Harry Campbell, Wim van der Hoek, RESCEU Investigators Estimating transmission parameters for respiratory syncytial virus and predicting the impact of maternal and pediatric vaccination JID. 2020 [21 August 2020];jiaa424.

https://doi.org/10.1093/infdis/jiaa424
14

You Li, Harry Campbell, Harish Nair, RESCEU Investigators Unveiling the risk period for mortality after respiratory syncytial virus illness in young children using a self-controlled case series design JID. 2020 [14 August 2020]; jiaa309

https://doi.org/10.1093/infdis/jiaa309
13

Deniz Öner, Simon B Drysdale, Calum McPherson, Gu-Lung Lin, Sophie Janet, Jonathan Broad, Andrew J Pollard, Jeroen Aerssens, RESCEU Investigators Biomarkers for disease severity in children infected with respiratory syncytial virus (RSV): a systematic literature review JID. 2020 [14 August 2020];jiaa208

https://doi.org/10.1093/infdis/jiaa208
12

Joanne G Wildenbeest, Roy P Zuurbier, Koos Korsten, Marlies A van Houten, Marie N Billard, Nicole Derksen-Lazet, Matthew D Snape, Simon B Drysdale, Hannah Robinson, Andrew J Pollard, Terho Heikkinen, Steve Cunningham, Amanda Leach, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Louis J Bont, Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe JID. 2020 [14 August 2020]; jiaa310

https://doi.org/10.1093/infdis/jiaa310
11

Kimberley Jefferies, Simon B Drysdale, Hannah Robinson, Elizabeth Ann Clutterbuck, Luke Blackwell, Joseph McGinley, Gu-Lung Lin, Ushma Galal, Harish Nair, Jeroen Aerssens, Deniz Öner, Annefleur Langedijk, Louis Bont, Joanne G Wildenbeest, Federico Martinon-Torres, Carmen Rodríguez-Tenreiro Sánchez, Simon Nadel, Peter Openshaw, Ryan Thwaites, Myra Widjojoatmodjo, et. al. Presumed risk factors and biomarkers for severe RSV disease and related sequelae. Protocol for an observational multi-centre, case-control study JID. 2020 [14 August 2020]; jiaa239

https://doi.org/10.1093/infdis/jiaa239
10

Roy P Zuurbier, Louis J Bont, Annefleur C Langedijk, Mirjam Hamer, Koos Korsten, Simon B Drysdale, Matthew D Snape, Hannah Robinson, Andrew J Pollard, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Ana Isabel Dacosta-Urbieta, Terho Heikkinen, Steve Cunningham, Marlies A van Houten, Joanne G Wildenbeest, for the RESCEU Investigators. Low sensitivity of BinaxNOW® RSV in infants. JID. 2020 [ 30 March 2020]; jiaa050.

https://doi.org/10.1093/infdis/jiaa050
09

Dexter J Wiseman, Ryan S Thwaites, Simon B Drysdale, Sophie Janet, Gavin C Donaldson, Jadwiga A Wedzicha, Peter J Openshaw, the RESCEU Investigators. Immunological and Inflammatory Biomarkers of susceptibility and severity in Adult RSV Infections. JID. 2020 [30 March 2020]; jiaa063.

https://doi.org/10.1093/infdis/jiaa063
08

Shanshan Zhang, Lily Zainal Akmar, Freddie Bailey, Barbara A Rath, Maren Alchikh, Brunhilde Schweiger, Marilla G Lucero, Leilani T Nillos, Moe H Kyaw, Alexia Kieffer, Sabine Tong, Harry Campbell, Philippe Beutels, Harish Nair. Cost of RSV-associated ALRI management in young children at the regional and global level – A systematic review and meta-analysis. JID. 2020 [ 30 March 2020]; jiz683.

https://doi.org/10.1093/infdis/jiz683
07

Pa Saidou Chaw, Lei Hua, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, et al. Respiratory Syncytial Virus Associated Acute Lower Respiratory Infections in Children with Bronchopulmonary dysplasia: Systematic Review and Meta-analysis. JID. 2019 [11 December 2019]; jiz492.

https://doi.org/10.1093/infdis/jiz492
06

Pa Saidou Chaw, Stephanie Wen Lan Wong, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, RESCEU Investigators. Acute Lower Respiratory Infections Associated with Respiratory Syncytial Virus in Children with Congenital Heart Disease: Systematic Review and Meta-analysis. JID. 2019 [10 October 2019]; jiz150.

https://doi.org/10.1093/infdis/jiz150
05

Amir Kirolos, Sara Manti, Rachel Blacow, Gabriel Tse, Thomas Wilson, Martin Lister, Stseve Cunningham, Alasdair Campbell, Harish Nair, Rachel M Reeves, Ricardo M Fernandes, Harry Campbell, RESCEU Investigator. A systematic review of clinical practice guidelines for the diagnosis and management of bronchiolitis. JID. 2019 [14 August 2019]; jiz240.

https://doi.org/10.1093/infdis/jiz240
04

Ting Shi, Yujing Ooi, Ei Mon Zaw, Natasa Utjesanovic, Harry Campbell, Steve Cunningham, Louis Bont, Harish Nair, RESCEU Investigators. Association between respiratory syncytial virus associated acute lower respiratory infection in early life and subsequent recurrent wheeze and asthma in later childhood. JID. 2019 [01 August 2019]; jiz311.

https://doi.org/10.1093/infdis/jiz311
03

Ting Shi, Angeline Denouel, Anna K Tietjen, Iain Campbell, Emily Moran, Xue Li, Harry Campbell, Clarisse Demont, Bryan O Nyawanda, Helen Y Chu, Sonia K Stoszek, Anand Krishnan, Peter Openshaw, Ann R Falsey, Harish Nair. Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis. JID. 2019 [18 March 2019]; jiz059.

https://doi.org/10.1093/infdis/jiz059
02

Ting Shi, Andrew Arnott, Indre Semogas, Ann R Falsey, Peter Openshaw, Jadwiga A Wedzicha, Harry Campbell, Harish Nair. The etiological role of common respiratory viruses in acute respiratory infections in older adults: A systematic review and meta-analysis. JID. 2019 [08 March 2019]; jiy662.

https://doi.org/10.1093/infdis/jiy662
01

Ting Shi, Angeline Denouel, Anna K Tietjen, Jen Wei Lee, Ann R Falsey, Clarisse Demont, Bryan O Nyawanda, Bing Cai, Robert Fuentes, Sonia K Stoszek, Peter Openshaw, Harry Campbell, Harish Nair. Global and regional burden of hospital admissions for pneumonia in older adults: A systematic review and meta-analysis. JID. 2019 [08 March 2019]; jiz053.

https://doi.org/10.1093/infdis/jiz053