De novo protein design enables the precise induction of RSV-neutralizing antibodies

Fabian Sesterhenn, Che Yang, Jaume Bonet, Johannes T Cramer, Xiaolin Wen, Yimeng Wang, Chi-I Chiang, Luciano A Abriata, Iga Kucharska, Giacomo Castoro, Sabrina S Vollers, Marie Galloux, Elie Dheilly, Stéphane Rosset, Patricia Corthésy, Sandrine Georgeon, Mélanie Villard, Charles-Adrien Richard, Delphyne Descamps, Teresa Delgado, Elisa Oricchio, Marie-Anne Rameix-Welti, Vicente Más, Sean Ervin, Jean-François Eléouët, Sabine Riffault, John T Bates, Jean-Philippe Julien, Yuxing Li, Theodore Jardetzky, Thomas Krey, Bruno E Correia


You can make your own computationally designed protein-based vaccine using TopoBuilder, a protein design algorithm. Sesterhenn and colleagues made a stable RSV F protein in prefusion conformation. They showed that this engineered protein was immunogenic in mice and induced neutralizing antibodies in non-human primates using prime-boost schemes. Neutralizing antibody levels was at least as high as palivizumab concentrations known to be protective. The vaccine may now be further developed. Obviously, this technology which allows generating vaccines against other pathogens has a promising future.

Full article on PubMed.