Acute Lower Respiratory Infections Associated with Respiratory Syncytial Virus in Children with Congenital Heart Disease: Systematic Review and Meta-analysis.

Pa Saidou Chaw, Stephanie Wen Lan Wong, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, RESCEU Investigators.


Respiratory syncytial virus (RSV) is the most common viral pathogen associated with acute lower respiratory infections (ALRIs), with significant childhood morbidity and mortality worldwide. Estimates reporting RSV-associated ALRI (RSV-ALRI) severity in children with congenital heart disease (CHD) are lacking, thus warranting the need to summarize the available data. We identified relevant studies to summarize the findings and conducted a meta-analysis of available data on RSV-associated ALRI hospitalizations in children aged <5 years, comparing those with underlying CHD to those without CHD.

We conducted a systematic search of existing relevant literature and identified studies reporting hospitalization of children aged <5 years with RSV-ALRI with underlying or no CHD. We summarized the data and conducted (where possible) a random-effects meta-analysis to compare the 2 groups.

Full article here.