Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data
Xin Wang, PhD * Prof You Li, PhD * Ting Shi, PhD Prof Louis J Bont, MD Helen Y Chu, MD Heather J Zar, PhD Bhanu Wahi-Singh, BMedSci Yiming Ma, MSc Bingbing Cong, BMed Emma Sharland, MBChB Prof Richard D Riley, PhD Jikui Deng, MD Prof Josep Figueras-Aloy, PhD Prof Terho Heikkinen, MD Prof Marcus H Jones, PhD Prof Johannes G Liese, MD Joško Markić, MD Asuncion Mejias, MD Prof Marta C Nunes Prof Bernhard Resch, MD Ashish Satav, MD Kee Thai Yeo, MD Prof Eric A F Simões, PhD Prof Harish Nair, PhD Respiratory Virus Global Epidemiology Network † for theRESCEU investigators†
New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic
Anne C. Teirlinck, Caroline K. Johannesen, Eeva K. Broberg, Pasi Penttinen, Harry Campbell, Harish Nair, Rachel M. Reeves, Håkon Bøås, Mia Brytting, Wei Cai, AnnaSara Carnahan, Jean-Sebastien Casalegno, Kostas Danis, Cillian De Gascun, Joanna Ellis, Hanne-Dorthe Emborg, Manuel Gijon, Raquel Guiomar, Siddhivinayak S. Hirve, Helena Jiřincová, Hanna Nohynek, Jesus Angel Oliva, Richard Osei-Yeboah, John Paget, Gatis Pakarna, Richard Pebody, Lance Presser, Marie Rapp, Janine Reiche, Ana Paula Rodrigues, Elina Seppälä, Maja Socan, Karol Szymanski, Ramona Trebbien, Jaromíra Večeřová, Sylvie van der Werf, Maria Zambon, Adam Meijer, Thea K. Fischer New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic Full article here
Cost-effectiveness of monoclonal antibody and maternal immunization against respiratory syncytial virus (RSV) in infants: Evaluation for six European countries
Abraham M. Getaneh, Xiao Li, Zhuxin Mao, Caroline K. Johannesen , Elisa Barbieri, Jojanneke van Summeren, Xin Wang , Sabine Tong, Eugenio Baraldi, Emily Phijffer, Caterina Rizzo, Maarten van Wijhe, Terho Heikkinen, Louis Bont, Lander Willem, Mark Jit, Philippe Beutels, Joke Bilcke, for Respiratory Syncytial Virus Consortium in Europe (RESCEU) investigators
Cost-Effectiveness of Respiratory Syncytial Virus Preventive Interventions in Children: A Model Comparison Study
Xiao Li, David Hodgson, Julien Flaig, Alexia Kieffer, William L.Herring, Hadi Beyhaghi, Lander Willem, Mark Jit, Joke Bilcke, Philippe Beutels, REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators
The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study
J G Wildenbeest, M-N Billard, Roy P Zuurbier, K Korsten, A CLangedijk, P Mvan de Ven, M D Snape, S BDrysdale, A J Pollard FMedSci, H Robinson,T Heikkinen, S Cunningham, T O’Neill, B Rizkalla, A Dacosta-Urbieta, F Martinón-Torres, M Avan Houten, L J Bont, RESCEU Investigators
Costs of management of acute respiratory infections in older adults: A systematic review and meta-analysis
Shanshan Zhang, Pia Wahi-Singh, Bhanu Wahi-Singh, Alison Chisholm, Polly Keeling, Harish Nair, RESCEU Investigators
Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults
Roy P Zuurbier, Koos Korsten, Theo J M Verheij, Chris Butler, Niels Adriaenssens, Samuel Coenen, Olivier Gruselle, Valerie Vantomme, Marlies A van Houten, Louis J Bont, Joanne G Wildenbeest, REspiratory Syncytial Virus Consortium in EUrope (RESCEU) Investigators
A Retrospective Cohort Study on Infant Respiratory Tract Infection Hospitalizations and Recurrent Wheeze and Asthma Risk: Impact of Respiratory Syncytial Virus
Maarten van Wijhe, Caroline Klint Johannesen, Lone Simonsen, Inger Merete Jørgensen, the RESCEU Investigators , Thea K Fischer
Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years
Guy Berbers, Liesbeth Mollema, Fiona van der Klis, Gerco den Hartog, Rutger Schepp
Estimating Transmission Parameters for Respiratory Syncytial Virus and Predicting the Impact of Maternal and Pediatric Vaccination
Michiel van Boven, Anne C Teirlinck, Adam Meijer, Mariëtte Hooiveld, Christiaan H van Dorp, Rachel M Reeves, Harry Campbell, Wim van der Hoek, RESCEU Investigators
Current practices for respiratory syncytial virus surveillance across the EU/EEA Member States, 2017
Madelief Mollers, Céline Barnadas, Eeva K Broberg, Pasi Penttinen, European Influenza Surveillance Network, Anne C Teirlinck, Thea K Fischer
Global Disease Burden of Respiratory Syncytial Virus in Preterm Children in 2019: A Systematic Review and Individual Participant Data Meta-Analysis Protocol
Xin Wang, You Li, Ting Shi, Yiming Ma, Bhanu Wahi-Singh, Richard D Riley, Harish Nair
A Retrospective Cohort Study on Infant Respiratory Tract Infection Hospitalizations and Recurrent Wheeze and Asthma Risk: Impact of Respiratory Syncytial Virus
van Wijhe M, Johannesen CK, Simonsen L, Jørgensen IM; RESCEU Investigators, Fischer TK.
Cost-effectiveness of Respiratory Syncytial Virus Disease Prevention Strategies: Maternal Vaccine Versus Seasonal or Year-Round Monoclonal Antibody Program in Norwegian Children
Li X, Bilcke J, Vázquez Fernández L, Bont L, Willem L, Wisløff T, Jit M, Beutels P; REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators.
Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection
McGinley JP, Lin GL, Öner D, Golubchik T, O’Connor D, Snape MD, Gruselle O, Langedijk AC, Wildenbeest J, Openshaw P, Nair H, Aerssens J, Bont L, Martinón-Torres F, Drysdale SB, Pollard AJ; RESCEU Investigators.
Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials
Billard MN, Wildenbeest J, Bont LJ, Nair H, McCracken JP, Oude Rengerink K; RESCEU Investigators.
Age-Specific Estimates of Respiratory Syncytial Virus-Associated Hospitalizations in 6 European Countries: A Time Series Analysis
Johannesen CK, van Wijhe M, Tong S, Fernández LV, Heikkinen T, van Boven M, Wang X, Bøås H, Li Y, Campbell H, Paget J, Stona L, Teirlinck A, Lehtonen T, Nohynek H, Bangert M, Fischer TK; RESCEU Investigators.
A Systematic Review of European Clinical Practice Guidelines for Respiratory Syncytial Virus Prophylaxis
Reeves RM, van Wijhe M, Lehtonen T, Stona L, Teirlinck AC, Vazquez Fernandez L, Li Y, Osei-Yeboah R, Fischer TK, Heikkinen T, van Boven M, Bøås H, Donà D, Barbieri E, Campbell H; RESCEU Investigators.
Economic Burden and Health-Related Quality of Life of Respiratory Syncytial Virus and Influenza Infection in European Community-Dwelling Older Adults
Mao Z, Li X, Korsten K, Bont L, Butler C, Wildenbeest J, Coenen S, Hens N, Bilcke J, Beutels P; RESCEU Investigators.
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis
You Li, Xin Wang, Diana M. Blau, Mauricio T. Caballero, Daniel R. Feikin, Cristopher J. Gill, Shabir A Madhi, Saad B. Omer, Eric A. F. Simoes, et al.
Patient Involvement in RSV Research: Towards Patients Setting the Research Agenda
Nicole D Derksen-Lazet, Corline E J Parmentier, Joanne G Wildenbeest, Louis J Bont, RESCEU Investigators
The burden of respiratory syncytial virus (RSV) associated acute lower respiratory infections in children with Down syndrome: A systematic review and meta-analysis
Markus Chan, John J Park, Ting Shi, Federico Martinón-Torres, Louis Bont, Harish Nair, Respiratory Syncytial Virus Network (ReSViNET)
Use of the moving epidemic method (MEM) to assess national surveillance data for respiratory syncytial virus (RSV) in the Netherlands, 2005 to 2017
Laura M Vos, Anne C Teirlinck, José E Lozano, Tomás Vega, Gé A Donker, Andy Im Hoepelman, Louis J Bont, Jan Jelrik Oosterheert, Adam Meijer
Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants
Sjanna B Besteman, Amie Callaghan, Marije P Hennus, Geertje H A Westerlaken, Linde Meyaard, Louis L Bont
Performance Assessment of a Rapid Molecular Respiratory Syncytial Virus Point-of-Care Test: A Prospective Community Study in Older Adults
Roy P Zuurbier, Koos Korsten, Theo J M Verheij, Chris Butler, Niels Adriaenssens, Samuel Coenen, Olivier Gruselle, Valerie Vantomme, Marlies A van Houten, Louis J Bont, Joanne G Wildenbeest, REspiratory Syncytial Virus Consortium in EUrope (RESCEU) Investigators
Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter?
Jojanneke van Summeren, Adam Meijer, Guðrún Aspelund, Jean Sebastien Casalegno, Guðrún Erna, Uy Hoang, Bruno Lina, VRS study group in Lyon; Simon de Lusignan, Anne C Teirlinck, Valtýr Thors, John Paget
Global molecular diversity of RSV – the “INFORM RSV” study
A C Langedijk, R J Lebbink, C Naaktgeboren, A Evers, M C Viveen, A Greenough, et al.
Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series
Yvette N Löwensteyn, Harish Nair, Marta C Nunes, Ichelle van Roessel, Femke S Vernooij, Joukje Willemsen, Louis J Bont, Natalie I Mazur, FLU GOLD study group
Describing global pediatric RSV disease at intensive care units in GAVI-eligible countries using molecular point-of-care diagnostics: the RSV GOLD-III study protocol
Yvette N Löwensteyn, Natalie I Mazur, Harish Nair, Joukje E Willemsen, Ghislaine van Thiel, Louis Bont, RSV GOLD III—ICU Network study group
Defining asthma in children: how well do parents, doctors and spirometry agree?
Koos Korsten, Christiana A Naaktgeboren, Louis J Bont, Cornelis K van der Ent, Marieke L A de Hoog
Current practices for respiratory syncytial virus surveillance across the EU/EEA Member States, 2017
Madelief Mollers, Céline Barnadas, Eeva K Broberg, Pasi Penttinen, Anne C Teirlinck, Thea K Fischer, European Influenza Surveillance Network
Study Pre-protocol for “BronchStart – The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study”
Thomas C Williams, Mark D Lyttle, Steve Cunningham, Ian Sinha, Olivia V Swann, Abigail Maxwell-Hodkinson, Robin Marlow, Damian Roland, Paediatric Emergency Research in the UK and Ireland (PERUKI)
Respiratory Syncytial Virus–Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries
Wang X, Li Y, Vazquez Fernandez L, Teirlinck AC, Lehtonen T, van Wijhe M, Stona L, Bangert M, Reeves RM, Bøås H, van Boven M, Heikkinen T, Klint Johannesen C, Baraldi E, Donà D, Tong S, Campbell H
Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe – the RESCEU Study
Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C Butler, Jean-Yves Pirçon, Theo J M Verheij, Louis J Bont, Joanne G Wildenbeest, RESCEU Investigators
World Health Organization Influenza-Like Illness Underestimates the Burden of Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults
Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C Butler, Theo J M Verheij, Louis J Bont, Joanne G Wildenbeest, RESCEU Investigators.
Recommendations for respiratory syncytial virus surveillance at the national level
Teirlinck AC, Broberg EK, Stuwitz Berg A, Campbell H, Reeves RM, Carnahan A, et al.
A Systematic Review and Meta-analysis of Animal Studies Investigating the Relationship Between Serum Antibody, T Lymphocytes, and Respiratory Syncytial Virus Disease
Joseph McGinley, Ryan Thwaites, Will Brebner, Lewis Greenan-Barrett, Jeroen Aerssens, Deniz Öner, Louis Bont, Joanne Wildenbeest, Federico Martinón-Torres, Harish Nair, Andrew J Pollard, Peter Openshaw, Simon Drysdale, RESCEU Investigators
Time-Varying Association Between Severe Respiratory Syncytial Virus Infections and Subsequent Severe Asthma and Wheeze and Influences of Age at the Infection
Wang X, Li Y, Nair H, Campbell H; RESCEU Investigators
Disease Burden Estimates of Respiratory Syncytial Virus related Acute Respiratory Infections in Adults With Comorbidity: A Systematic Review and Meta-Analysis
Shi T, Vennard S, Jasiewicz F, Brogden R, Nair H; RESCEU Investigators
Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
Gu-Lung Lin, Simon B Drysdale, Matthew D Snape, Daniel O’Connor, Anthony Brown, George MacIntyre-Cockett, Esther Mellado-Gomez, Mariateresa de Cesare, David Bonsall, M Azim Ansari, Deniz Öner, Jeroen Aerssens, Christopher Butler, Louis Bont, Peter Openshaw, Federico Martinón-Torres, Harish Nair, Rory Bowden, RESCEU Investigators; Tanya Golubchik, Andrew J Pollard
Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study
Rosalie S Linssen, Anne C Teirlinck, Michiel van Boven, Dominique Biarent, Luca Stona, Angela Amigoni, Rosanna I Comoretto, Stephane Leteurtre, Amélie Bruandet, Gunnar K Bentsen, Inger Marie Drage, Xin Wang, Harry Campbell, Job B M van Woensel, Louis Bont, Reinout A Bem
Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units
Rosalie S Linssen, Reinout A Bem, Berber Kapitein, Katrien Oude Rengerink, Marieke H Otten, Bibiche den Hollander, Louis Bont, Job B M van Woensel
Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study
Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators
Exploratory Analysis of the Economically Justifiable Price of a Hypothetical RSV Vaccine for Older Adults in the Netherlands and the United Kingdom
F Zeevat, J Luttjeboer, J H J Paulissen, J van der Schans, P Beutels, C Boersma, M J Postma, RESCEU Investigators
Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units
Linssen RS, Bem RA, Kapitein B, Rengerink KO, Otten MH, den Hollander B, Bont L, van Woensel JBM Summary High flow oxygen intends to decrease work of breathing and prevent respiratory failure. Despite trials have shown benefit, high flow oxygen has not brought the success hoped for as it did not decrease the need for …
Respiratory syncytial virus seasonality and prevention strategy planning for passive immunisation of infants in low-income and middle-income countries: a modelling study
Li Y, Hodgson D, Wang X, Atkins KE, Feikin DR, Nair H Summary As soon as the temperature goes down by the end of summer and the beginning of fall, viruses are lurking around the corner. RSV is also such a virus, which has a clear seasonality in most countries. Maternal vaccination and passive immunization …
Burden of Respiratory Syncytial Virus Infection During the First Year of Life
Thomas E, Mattila JM, Lehtinen P, Vuorinen T, Waris M, Heikkinen T Summary RSV is the number one cause of hospitalization for acute lower respiratory tract infection in infants. Moreover, RSV affects an even bigger group of non-hospitalized children. Thomas and his colleagues decided to investigate the burden of RSV infection in this under-recognized patient …
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Risk factors for RSV associated acute lower respiratory infection poor outcome and mortality in young children: A systematic review and meta-analysis
Ting Shi, Sophie Vennard, Sara Mahdy, Harish Nair
The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019–Related Public Health Measures
Foley DA, Yeoh DK, Minney-Smith CA, Martin AC, Mace AO, Sikazwe CT, Le H, Levy A, Moore HC, Blyth CC Summary During the current COVID-19 pandemic, RSV infections have fallen of the radar. We have seen a tremendous decrease in RSV infection rates, which usually peak during the fall and winter seasons. This raises the …
Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins
Rutger M. Schepp, Cornelis A. M. de Haan, Deidre Wilkins, Hans Layman, Barney S. Graham, Mark T. Esser, Guy A. M. Berbers
Epidemiology and Immune Pathogenesis of Viral Sepsis
Gu-Lung Lin, Joseph P. McGinley, Simon B. Drysdale, Andrew J. Pollard
Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries.
Li X, Willem L, Antillon M, Bilcke J, Jit M, Beutels P.
Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants
Lin GL, Golubchik T, Drysdale S, O’Connor D, Jefferies K, Brown A, de Cesare M, Bonsall D, Ansari MA, Aerssens J, Bont L, Openshaw P, Martinón-Torres F, Bowden R, Pollard AJ; RESCEU Investigators.
Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis
Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, Moore DP, Nunes M, Rath B, Campbell H, Nair H; RSV Global Epidemiology Network; RESCEU investigators.
Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study
Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators.
Adenovirus vector containing RSV preF induces neutralizing antibodies
Sadoff J, De Paepe E, DeVincenzo J, Gymnopoulou E, Menten J, Murray B, Bastian AR, Vandebosch A, Haazen W, Noulin N, Comeaux C, Heijnen E, Eze K, Gilbert A, Lambkin-Williams R, Schuitemaker H, Callendret B Summary Janssen Pharmaceuticals has shown that a single intramuscular injection with an adenovector (Ad26) -based RSV vaccine is highly immunogenic …
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Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome
Ghazaly MMH, Faddan NHA, Raafat DM, Mohammed NA, Nadel S Summary Sepsis, trauma, burn, and transfusion related lung injury are known causes of pediatric ARDS, an alveolar disease leading to hypoxemia. Viral respiratory infection has been mentioned as a more rare cause of ARDS, but the role of individual viruses, such as RSV, is understudied. …
Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection
Maximillian S Habibi Ryan S Thwaites, Meiping Chang, Agnieszka Jozwik, Allan Paras, Freja Kirsebom, Augusto Varese, Amber Owen, Leah Cuthbertson, Phillip James, Tanushree Tunstall, David Nickle, Trevor T Hansel, Miriam F Moffatt, Cecilia Johansson, Christopher Chiu, Peter J M Openshaw Summary Why does RSV exposure in one individual lead to disease, while another individual does not experience symptoms at all? Besides, how can a virus reinfect individuals that already have …
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RSV-associated hospital admissions in children younger than five years in seven European countries using routinely collected datasets
Rachel M Reeves, Maarten van Wijhe, Sabine Tong, Toni Lehtonen, Luca Stona, Anne C Teirlinck, Liliana Vazquez Fernandez, You Li, Carlo Giaquinto, Thea Kølsen Fischer, Clarisse Demont, Terho Heikkinen, Irene Speltra, Michiel van Boven, Håkon Bøås, Harry Campbell, RESCEU Investigators
Hospital admission trends for bronchiolitis in Scotland, 2001-2016: a national retrospective observational study
Alexandria Chung, Rachel M Reeves, Harish Nair, Harry Campbell, RESCEU investigators
Estimating transmission parameters for respiratory syncytial virus and predicting the impact of maternal and pediatric vaccination
Michiel van Boven, Anne C Teirlinck, Adam Meijer, Mariëtte Hooiveld, Christiaan H van Dorp, Rachel M Reeves, Harry Campbell, Wim van der Hoek, RESCEU Investigators
Unveiling the risk period for mortality after respiratory syncytial virus illness in young children using a self-controlled case series design
You Li, Harry Campbell, Harish Nair, RESCEU Investigators
Biomarkers for disease severity in children infected with respiratory syncytial virus (RSV): a systematic literature review
Deniz Öner, Simon B Drysdale, Calum McPherson, Gu-Lung Lin, Sophie Janet, Jonathan Broad, Andrew J Pollard, Jeroen Aerssens, RESCEU Investigators
Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe
Joanne G Wildenbeest, Roy P Zuurbier, Koos Korsten, Marlies A van Houten, Marie N Billard, Nicole Derksen-Lazet, Matthew D Snape, Simon B Drysdale, Hannah Robinson, Andrew J Pollard, Terho Heikkinen, Steve Cunningham, Amanda Leach, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Louis J Bont, Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators
Presumed risk factors and biomarkers for severe RSV disease and related sequelae. Protocol for an observational multi-centre, case-control study
Kimberley Jefferies, Simon B Drysdale, Hannah Robinson, Elizabeth Ann Clutterbuck, Luke Blackwell, Joseph McGinley, Gu-Lung Lin, Ushma Galal, Harish Nair, Jeroen Aerssens, Deniz Öner, Annefleur Langedijk, Louis Bont, Joanne G Wildenbeest, Federico Martinon-Torres, Carmen Rodríguez-Tenreiro Sánchez, Simon Nadel, Peter Openshaw, Ryan Thwaites, Myra Widjojoatmodjo, et. al.
Live-attenuated Vaccines Prevent Respiratory Syncytial Virus-associated Illness in Young Children
Ruth A Karron, Jessica E Atwell, Elizabeth J McFarland, Coleen K Cunningham, Petronella Muresan, Charlotte Perlowski, Jennifer Libous, Stephen A Spector, Ram Yogev, Mariam Aziz, Suzanne Woods, Kimberli Wanionek, Peter L Collins, Ursula J Buchholz Summary Live-attenuated RSV vaccines are probably effective in young children. This is an important conclusion from Ruth Karron and co-workers after analyzing data from seven previous trials. According to the PATH snapshot of …
Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants
S.A. Madhi, F.P. Polack, P.A. Piedra, F.M. Munoz, A.A. Trenholme, E.A.F. Simões, G.K. Swamy, S. Agrawal, K. Ahmed, A. August, A.H. Baqui, A. Calvert, J. Chen, I. Cho, M.F. Cotton, C.L. Cutland, J.A. Englund, A. Fix, B. Gonik, L. Hammitt, P.T. Heath, J.N. de Jesus, C.E. Jones, A. Khalil, D.W. Kimberlin, R. Libster, C.J. Llapur, …
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De novo protein design enables the precise induction of RSV-neutralizing antibodies
Fabian Sesterhenn, Che Yang, Jaume Bonet, Johannes T Cramer, Xiaolin Wen, Yimeng Wang, Chi-I Chiang, Luciano A Abriata, Iga Kucharska, Giacomo Castoro, Sabrina S Vollers, Marie Galloux, Elie Dheilly, Stéphane Rosset, Patricia Corthésy, Sandrine Georgeon, Mélanie Villard, Charles-Adrien Richard, Delphyne Descamps, Teresa Delgado, Elisa Oricchio, Marie-Anne Rameix-Welti, Vicente Más, Sean Ervin, Jean-François Eléouët, Sabine Riffault, John T Bates, Jean-Philippe Julien, Yuxing Li, Theodore Jardetzky, Thomas Krey, Bruno E Correia Summary You can make your own computationally designed protein-based vaccine using TopoBuilder, a protein design algorithm. Sesterhenn …
A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primates
Steffen Mueller, Charles B. Stauft, Raj Kalkeri, Fusataka Koidei, Anna Kushnir, Sybil Tasker, J. Robert Coleman Summary A novel codon-deoptimized RSV vaccine protected African Green Monkeys against viral replication and induced neutralizing antibodies as well as cellular IFNg response against RSV. Deoptimized vaccines are generated in vitro with the aim to impair replication in human …
Sustained Cellular and Humoral Immune Responses From an Adenoviral Vector-based Respiratory Syncytial Virus Vaccine
Koos Korsten and Louis J. Bont Summary This paper presents the results of a novel chimpanzee-derived replication-deficient adenoviral vector vaccine against RSV (ChAd155-RSV), based on 3 RSV viral proteins including F (fusion), N (nucleocapsid), and M2-1 (antitermination). Although the intended use is in the infant population, this phase 1 first-in-human study aimed to investigate safety, …
Molecular Epidemiology of Influenza, RSV, and Other Respiratory Infections among Children in Qatar: A six years report (2012-2017)
Al-Romaihi HE, Smatti MK, Al-Khatib HA, Coyle PV, Ganesan N, Ahmed SN, Farag EA, Thani AAA, Khal AA, Ansari KMA, Maslamani MAA, Yassine HM Summary This paper describes the results of a retrospective health record study conducted in Qatar analysing the records of paediatric cases of Influenza like infectious diseases between 2012 and 2017. This …
Low sensitivity of BinaxNOW® RSV in infants.
Roy P Zuurbier, Louis J Bont, Annefleur C Langedijk, Mirjam Hamer, Koos Korsten, Simon B Drysdale, Matthew D Snape, Hannah Robinson, Andrew J Pollard, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Ana Isabel Dacosta-Urbieta, Terho Heikkinen, Steve Cunningham, Marlies A van Houten, Joanne G Wildenbeest, for the RESCEU Investigators.
Immunological and Inflammatory Biomarkers of susceptibility and severity in Adult RSV Infections.
Dexter J Wiseman, Ryan S Thwaites, Simon B Drysdale, Sophie Janet, Gavin C Donaldson, Jadwiga A Wedzicha, Peter J Openshaw, the RESCEU Investigators.
Cost of RSV-associated ALRI management in young children at the regional and global level – A systematic review and meta-analysis.
Shanshan Zhang, Lily Zainal Akmar, Freddie Bailey, Barbara A Rath, Maren Alchikh, Brunhilde Schweiger, Marilla G Lucero, Leilani T Nillos, Moe H Kyaw, Alexia Kieffer, Sabine Tong, Harry Campbell, Philippe Beutels, Harish Nair.
Does viral load affect the severity of respiratory syncytial virus (RSV) disease in children?
Uusitupa E, Waris M, Heikkinen T. Summary Over the past years results on the associations between RSV loads and severe manifestations of the RSV illness were contradictory. Nevertheless, association between viral load and severity of illness in contributive for the use of antivirals in RSV disease. Heikkinen and colleagues conducted a prospective cohort study of …
Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage
Beth K Thielen, Erica Bye, Xiong Wang, Stacene Maroushek, Hannah Friedlander, Sarah Bistodeau, Jaime Christensen, Erik Reisdorf, Meghan H Shilts, Karen Martin, Kathryn Como-Sabetti, Anna K Strain, Patricia Ferrieri, Ruth Lynfield Summary This study describes a newly identified RSV strain that emerged in Minesota in the United states in summer 2017. The observed strain was …
Clinical burden of severe respiratory syncytial virus infection during the first 2 years of life in children born between 2000 and 2011 in Scotland
Richard Thwaites, Scot Buchan, John Fullarton, Carole Morris, ElizaBeth Grubb, Barry Rodgers-Gray, Jonathan Coutts Summary This paper surveyed national birth data for Scotland between the years of 2000 and 2011, providing the first study of the burden of RSV in Scotland, with an appreciable sample size of over 600000 patients. Hospitalised cases of RSV were …
Neutrophil-endothelial interactions in respiratory syncytial virus bronchiolitis, a potential for prediction of severity of disease?
Juliana A, Zonneveld R, Plötz FB, van Meurs M, Wilschut J. Summary The exact molecular mechanism of neutrophil migration into the airway in respiratory syncytial virus (RSV) infection is little studied. This paper reviews the to date evidence of activation of endothelial cells and neutrophils, interaction of neutrophils with endothelial cells and migration across endothelial cells in Respiratory Syncytial …
Epidemic dynamics of respiratory syncytial virus in current and future climates
Rachel E. Baker, Ayesha S. Mahmud, Caroline E. Wagner, Wenchang Yang, Virginia E. Pitzer, Cecile Viboud, Gabriel A. Vecchi, C. Jessica E. Metcalf, and Bryan T. Grenfell Summary The impact of climate on viral epidemiology has been documented in the past, particularly in the field of influenza, however it has remained poorly understood in RSV, …
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A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients.
Chemaly RF, Dadwal SS, Bergeron A, Ljungman P, Kim YJ, Cheng GS, Pipavath SN, Limaye AP, Blanchard E, Winston DJ, Stiff PJ, Zuckerman T, Lachance S, Rahav G, Small CB, Mullane KM, Patron RL, Lee DG, Hirsch HH, Waghmare A, McKevitt M, Jordan R, Guo Y, German P, Porter DP, Gossage DL, Watkins TR, Marty …
Respiratory Syncytial Virus Associated Acute Lower Respiratory Infections in Children with Bronchopulmonary dysplasia: Systematic Review and Meta-analysis.
Pa Saidou Chaw, Lei Hua, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, et al.
Clinical characteristics, predictors, and performance of case definition—Interim results from the WHO global respiratory syncytial virus surveillance pilot
Siddhivinayak Hirve, Nigel Crawford, Rakhee Palekar, Wenqing Zhang, on behalf of the WHO RSV surveillance Group Summary Since 2016, the WHO have been conducting a pilot study aimed at leveraging the capacity of the currently existing Global Influenza Surveillance and Response System (GISRS) to survey the global yearly epidemics of RSV and their impact on …
RSV/NS2/1313/I1314L vaccine in RSV-seronegative children is safe and immunogenic
Ruth A. Karron, Cindy Luongo, Jocelyn San Mateo, Kimberli Wanionek, Peter L. Collins, Ursula J. Buchholz, and the RSVPed Team Summary The RSV/DNS2/D1313/I1314L is an intranasal vaccine that contains two attenuating elements in the RSV strain: deletion of the NS2 gene and deletion of the codon 1313. The deletions are stabilized with the substitution of …
Risk of childhood wheeze and asthma after respiratory syncytial virus infection in full‐term infants
Asuncion Mejias, Bingcao Wu, Neeta Tandon, Wing Chow, Ram Varma, Eduardo Franco, Octavio Ramilo Summary Most studies that have looked at the relationship between RSV and further respiratory sequelae such as asthma and wheeze have been performed in premature infants, or infants with other risk factors, as a result few studies have been conducted on …
Acute Lower Respiratory Infections Associated with Respiratory Syncytial Virus in Children with Congenital Heart Disease: Systematic Review and Meta-analysis.
Pa Saidou Chaw, Stephanie Wen Lan Wong, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, RESCEU Investigators.
Low resistance against a novel highly potent site IV antibody
Tang A, Chen Z, Cox KS, Su HP, Callahan C, Fridman A, Zhang L, Patel SB, Cejas PJ, Swoyer R, Touch S, Citron MP, Govindarajan D, Luo B, Eddins M, Reid JC, Soisson SM, Galli J, Wang D, Wen Z, Heidecker GJ, Casimiro DR, DiStefano DJ, Vora KA. Summary RB1 is a humanized monoclonal antibody that binds to site IV of the RSV F glycoprotein and is 50 times more potent than palivizumab. Tang and colleagues describe the …
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Respiratory syncytial virus infection among adults during influenza season: A frequently overlooked diagnosis
Javier Martínez‐Sanz, Sergio Gilaberte Reyzábal, Juan Salillas, María Rosa Lago Gómez, M. Elena Rodríguez‐Zurita, Miguel Torralba Summary Many epidemiological studies of RSV have observed a sharp drop off of RSV infections with the coming of influenza season in late December and early January. Whether or not RSV incidence falls off with the influx of influenza …
Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis
Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, Moore DP, Nunes M, Rath B, Campbell H, Nair H; RSV Global Epidemiology Network; RESCEU investigators. Summary The relationships between the seasonalities of RSV, Influenza Virus and Parainfluenza virus remain poorly understood, and a robust predictive model for epidemics has not yet been developed in the case of RSV. While the consistent and predictable temporal relationship between …
DS-Cav1 beats previous subunit RSV vaccines
Crank MC, Ruckwardt TJ, Chen M, Morabito1 KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT, Schwartz RM, Kueltzo1 L, Cooper JW, Chen P, Stein JA, Carlton1 K, Gall JG, Nason MC, Kwong PD, Chen1 GL, Mascola JR,McLellan JS, Ledgerwood JE, Graham BS, …
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A systematic review of clinical practice guidelines for the diagnosis and management of bronchiolitis.
Amir Kirolos, Sara Manti, Rachel Blacow, Gabriel Tse, Thomas Wilson, Martin Lister, Stseve Cunningham, Alasdair Campbell, Harish Nair, Rachel M Reeves, Ricardo M Fernandes, Harry Campbell, RESCEU Investigator.
Association between respiratory syncytial virus associated acute lower respiratory infection in early life and subsequent recurrent wheeze and asthma in later childhood.
Ting Shi, Yujing Ooi, Ei Mon Zaw, Natasa Utjesanovic, Harry Campbell, Steve Cunningham, Louis Bont, Harish Nair, RESCEU Investigators.
Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses
Lam TT, Tang JW, Lai FY, Zaraket H, Dbaibo G, Bialasiewicz S, Tozer S, Heraud JM, Drews SJ, Hachette T, Chan PK, Koay ES, Lee HK, Tee KK, Liu Y, Fraaij P, Jennings L, Waris M, Krajden M, Corriveau A, Jalal H, Nishimura H, Nymadawa P, Badarch D, Watanabe A, Kabanda A, Sloots T, Kok J, Dwyer DE, Koopmans M, INSPIRE (International Network for the Sequencing of Respiratory Viruses). Summary The results of a large trial monitoring the incidence of a range of respiratory viruses across 18 …
RSV and the microbiome
Alejandro Diaz-Diaz, Cristina Garcia-Maurino, Alejandro Jordan-Villegas, Jeffrey Naples, Octavio Ramilo and Asuncion Mejias Summary Antimicrobial resistance (AMR) is one of the biggest threats to mankind. It is related to massive use of antibiotics for bacterial infection, in particular respiratory infections. Antibiotics are also used, often unnecessary in case of respiratory viral infections, including RSV infection. However, recent studies suggest …
Incidence of Respiratory Syncytial Virus Bronchiolitis in Hospitalized Infants Born at 33-36 Weeks Gestational Age Compared with those Born at Term: A Retrospective Cohort Study
Greenberg D, Dagan R, Shany E, Ben-Shimol S, Givon-Lavi N. Summary A retrospective cohort study conducted in Soroka, Israel that compared the incidence rates of RSV Bronchiolitis among pre term (33-36 weeks gestational age) children, and those born at term. Rate of bronchiolitis in the general population were extrapolated from the numbers collected in hospital. …
A do-it-yourself toolbox to make an RSV vaccine.
Jessica Marcandalli, Brooke Fiala, Sebastian Ols, …, Karin Lore´ , Laurent Perez, Neil P. King Summary Self-assembling proteins are promising inducers of a strong antibody response, because they enable multivalent antigen presentation. Jessica Marcandalli and colleagues designed such a self-assembling protein nanoparticle vaccine, based on prefusion-stabilized RSV-F antigen. It is a computational vaccine that consists …
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Respiratory syncytial virus-associated hospitalisations in Australia, 2006-2015.
Saravanos GL, Sheel M, Homaira N, Dey A, Brown E, Wang H, Macartney K, Wood NJ. Summary Saravanos et al provide a long term and comprehensive study of Respiratory Syncytial Virus infection in Australia. This study aimed to estimate hospitalisation rates across the whole Australian population, while paying attention to factors that may influence this, …
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The repertoire of maternal anti-viral antibodies in human newborns.
Pou C, Nkulikiyimfura D, Henckel E, Olin A, Lakshmikanth T, Mikes J, Wang J, Chen Y, Bernardsson AK, Gustafsson A, Bohlin K, Brodin P. Summary Virscan is a novel diagnostic tool to measure antibodies against >1000 viral strains. It shows previous viral exposures of an individual person. Christian Pou and colleagues used Virscan to get …
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Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis
Ting Shi, Angeline Denouel, Anna K. Tietjen, Iain Campbell, Emily Moran, Xue Li, Harry Campbell, Clarisse Demont, Bryan O. Nyawanda, Helen Y. Chu, Sonia K. Stoszek, Anand Krishnan, Peter Openshaw, Ann R. Falsey, and Harish Nair, for the RESCEU Investigators Summary Shi and colleagues conducted a systemtic review and meta analysis of the global burden …
The endangered future of Syngem, a novel bacterium-like particle based, needle-free, RSV vaccine
Ascough S, Vlachantoni I, Kalyan M, Haijema BJ, Wallin- Weber S, Dijkstra-Tiekstra M, Ahmed MS, Roosmalen M van, Grimaldi R, Zhang Q, Leenhouts K, Openshaw PJ and Chiu C. Summary Despite numerous years of research we are still lacking a safe and effective RSV vaccine. This process is hindered by numerous problems: the lack of a correlate …
High incidence of RSV illness in Malian infants, primarily caused by RSV-B
Andrea G. Buchwald, Boubou Tamboura, Sharon M. Tennant, Fadima C. Haidara, Flanon Coulibaly, Moussa Doumbia, Fatoumata Diallo, Adama M. Keita, Samba O. Sow, Karen L. Kotloff, Myron M. Levine, Milagritos D. Tapia. Summary Buchwald and colleagues conducted an active community-based surveillance for RSV infection in Mali. 1871 infants were followed from birth to six months …
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Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis.
Ting Shi, Angeline Denouel, Anna K Tietjen, Iain Campbell, Emily Moran, Xue Li, Harry Campbell, Clarisse Demont, Bryan O Nyawanda, Helen Y Chu, Sonia K Stoszek, Anand Krishnan, Peter Openshaw, Ann R Falsey, Harish Nair.
The etiological role of common respiratory viruses in acute respiratory infections in older adults: A systematic review and meta-analysis.
Ting Shi, Andrew Arnott, Indre Semogas, Ann R Falsey, Peter Openshaw, Jadwiga A Wedzicha, Harry Campbell, Harish Nair.
Global and regional burden of hospital admissions for pneumonia in older adults: A systematic review and meta-analysis.
Ting Shi, Angeline Denouel, Anna K Tietjen, Jen Wei Lee, Ann R Falsey, Clarisse Demont, Bryan O Nyawanda, Bing Cai, Robert Fuentes, Sonia K Stoszek, Peter Openshaw, Harry Campbell, Harish Nair.
Respiratory syncytial virus and influenza hospitalisations by HIV status in South African children
Meredith L. McMorrow, Stefano Tempia, Sibongile Walaza, Florette K. Treurnicht, Jocelyn Moyes, Adam L. Cohen, Marthi Pretorius, Orienka Hellferscee, Nicole Wolter, Anne von Gottberg, Arthemon Nguweneza, Johanna M. McAnerney, Fathima Naby, Omphile Mekgoe, Marietjie Venter, Shabir A. Madhi, and Cheryl Cohen. The Role of Human Immunodeficiency Virus in Influenza- and Respiratory Syncytial Virus–associated Hospitalizations in …
Sample size required to detect the effect of RSV vaccination on recurrent wheezing
Riddell CA, Bhat N, Bont LJ, Dupont WD, Feikin DR, Fell DB, Gebretsadik T, Hartert TV, Hutcheon JA, Karron RA, Nair H, Reiner RC Jr, Shi T, Sly PD, Stein RT, Wu P, Zar HJ, Ortiz JR; WHO Technical Working Group on Respiratory Syncytial Virus Vaccination During Pregnancy to Prevent Recurrent Childhood Wheezing.Vaccine. 2018 Dec 18;36(52):8100-8109. doi: 10.1016/j.vaccine.2018.10.041. Epub 2018 Nov 22. Informing randomized clinical trials of respiratory syncytial virus vaccination during pregnancyto prevent recurrent childhood wheezing: A sample size analysis. Summary Riddell and colleagues investigated the feasibility of utilizing maternal RSV vaccine trials to detect the effect of RSV vaccine on …
Miniature lungs: the road towards a better model to study RSV disease
Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans …
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Morbidity and mortality in older adults with RSV vs. influenza infection
Bradley Ackerson, Hung Fu Tseng, Lina S. Sy, Zendi Solano, Jeff Slezak, Yi Luo, Christine A. Fischetti, Vivek Shinde in Clin Infect Dis. 2018 Nov 19. doi: 10.1093/cid/ciy991. [Epub ahead of print] Severe Morbidity And Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection In Hospitalized Older Adults Summary A large cohort of adults >=60 …
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Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation
Kempaiah Rayavara, Alexander Kurosky, Susan J. Stafford, Nisha J. Garg,Allan R. Brasier, Roberto P. Garofalo, and Yashoda M. Hosakote, J Immunol 2018; 201:2753-2766; Prepublished online 1 October 2018; http://www.jimmunol.org/content/201/9/2753 doi: 10.4049/jimmunol.1800558 Summary The first epithelial molecular events upon infection define the size and direction of the inflammatory response, which ultimately defines disease in RSV infected …
Patterns of respiratory pathogen circulation in rural coastal Kenya
Munywoki PK, Koech DC, Agoti CN, Cane PA, Medley GF, Nokes DJ. Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya. Clin Infect Dis. 2018 Oct 30;67(10):1559-1567. doi: 10.1093/cid/ciy313. Summary A household-based active surveillance during RSV season was conducted in 47 households in Kilifi Kenya. This study showed that 93.4% of the study participants had at least 1 virus detected. Adenovirus (AdV), human coronavirus (HCoV) and rhinovirus …
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The significance of Human Respiratory Syncytial Virus (HRSV) in children from Ghana with acute lower respiratory tract infection: a molecular epidemiology analysis
Obodai E, Odoom JK, Adiku T, Goka B, Wolff T, Biere B, Schweiger B, Reiche J. The significance of human respiratory syncytial virus (HRSV) in children from Ghana with acute lower respiratory tract infection: A molecular epidemiological analysis, 2006 and 2013-2014. PLoS One. 2018 Sep 10;13(9):e0203788. doi: 10.1371/journal.pone.0203788. eCollection 2018. Summary The molecular epidemiology of RSV infection is increasingly thought to be essential …
Implications of viral genomic variability for RSV immunisation programs
Vicente Mas, Nair H, Campbell H, Melero JA, Williams TC. Antigenic and sequence variability of the human respiratory syncytial virus F glycoproteincompared to related viruses in a comprehensive dataset. Vaccine. 2018 Oct 3. pii: S0264-410X(18)31325-2. doi: 10.1016/j.vaccine.2018.09.056; in press. Summary In this study Williams and colleagues examined variability in the RSV F glycoprotein from published data virus strains sequenced in different locations worldwide. Looking at the specific parts of the protein targeted …
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Respiratory viral epidemiology in rural Kenya
Nyiro JU, Munywoki P, Kamau E, Agoti C, Gichuki A, Etyang T, Otieno G, Nokes DJ. Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baselineepidemiological observations. Wellcome Open Res. 2018 Jul 25;3:89. doi: 10.12688/wellcomeopenres.14662.1. eCollection 2018. Summary This paper reports the epidemiological data of respiratory viruses at nine outpatient health facilities in rural coastal Kenya as well as in hospital settings. More than half (53.7%) of participants with ARI symptoms were from children …
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New insights into aetiology of neonatal infections
Saha SK, Schrag SJ, El Arifeen S, Mullany LC, Shahidul Islam M, Shang N, Qazi SA, Zaidi AKM, Bhutta ZA, Bose A, Panigrahi P, Soofi SB, Connor NE, Mitra DK, Isaac R, Winchell JM, Arvay ML, Islam M, Shafiq Y, Nisar I, Baloch B, Kabir F, Ali M, Diaz MH, Satpathy R, Nanda P, Padhi BK, Parida S, Hotwani A, Hasanuzzaman M, Ahmed S, Belal Hossain M, Ariff S, Ahmed I, Ibne Moin SM, Mahmud A, Waller JL, Rafiqullah I, Quaiyum MA, Begum N, Balaji V, Halen J, Nawshad Uddin Ahmed ASM, Weber MW, Hamer DH, Hibberd PL, Sadeq-Ur Rahman Q, Mogan …
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The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates
Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh …
RSV burden in HIV-infected mothers
Madhi SA, Cutland CL, Downs S, Jones S, van Niekerk N, Simoes EAF, Nunes MC.Burden of Respiratory Syncytial Virus Infection in South African Human Immunodeficiency Virus(HIV)-Infected and HIV Uninfected Pregnant and Postpartum Women: A Longitudinal Cohort Study. Clin InfectDis. 2018 May 17;66(11):1658-1665. Available from: doi: 10.1093/cid/cix1088. Summary A longitudinal cohort study from South Africa investigated the RSV burden in HIV-infected and HIV-uninfected women (from mid-pregnancy until 24 weeks of postpartum). The incidence of RSV illness in 2011 among HIV-infected women was …
Epidemiology of respiratory virus infection in preterm infants in a tropical area
Yeo KT, de la Puerta R, Tee NWS, Thoon KC, Rajadurai VS, Yung CF. Burden, etiology and risk factors of respiratory virus infections among symptomatic preterminfants in the tropics: a retrospective single-center cohort study. Clin Infect Dis. 2018 Apr 12, in press. Available from: doi: 10.1093/cid/ciy311 Summary A 11-year retrospective cohort data linkage study was performed in one hospital from Singapore to investigate the epidemiology of respiratory viral infections (RVIs). This study included 1854 preterm infants (born with ≤32 weeks of gestational age) admitted with laboratory confirmed RVIs before 2 years …
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Subcutaneous treatment with diabetes drug liraglutide (Victoza®) is effective treatment of RSV infection
Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV2, Niswender KD, Peebles RS Jr. Glucagon-like peptide-1 receptor signaling attenuates RSV-induced type 2 responses and immunopathology. J Allergy Clin Immunol. 2018 Apr 17,in press. Available from: pii: S0091-6749(18)30561-X. doi: 10.1016/j.jaci.2018.01.053. Summary The glucagon-like peptide(GLP)-1 receptor agonist liraglutide has the potential to be an effective treatment of RSV bronchiolitis. This …
RSV during infancy and childhood asthma: the puzzle remains
Scheltema NM, Nibbelke EE, Pouw J, Blanken MO, Rovers MM, Naaktgeboren CA, Mazur NI, Wildenbeest JG, van der Ent CK, Bont LJ. Respiratory syncytial virus prevention and asthma in healthy preterm infants: a randomised controlled trial. Lancet Respir Med. 2018 Feb 27; in press. Available from: doi: 10.1016/S2213-2600(18)30055-9. Summary A 6-year single-blind, randomised, placebo-controlled trial (MAKI) was carried out to evaluate the effect of RSV prevention during infancy on asthma and lung function at …
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RSV Hospitalisation: Preterm Infants with CLD Compared to Term Infants
Winterstein AG, Choi Y, Meissner HC. Association of Age With Risk of Hospitalization for Respiratory Syncytial Virus in Preterm Infants With Chronic Lung Disease, JAMA Pediatr. 2018 Feb 1;172(2):154-160, in press. Available from: doi: 10.1001/jamapediatrics.2017.3792. Summary American Academy of Pediatrics guidelines recommends RSV prophylaxis with palivizumab up to 24 months age for infants with chronic lung disease (CLD). Winterstein and colleagues conducted a …
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Respiratory Syncytial Virus Seasonality: A Global Overview
Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, Rodríguez-Tenreiro C, Sly P, Ramilo O, Mejías A, Baraldi E, Papadopoulos NG, Nair H, Nunes MC, Kragten-Tabatabaie L, Heikkinen T, Greenough A, Stein RT, Manzoni P, Bont L, Martinón-Torres F, ReSViNET. Respiratory Syncytial Virus Seasonality: A Global Overview, J Infect Dis. 2018 Jan 30, in press. Available from: doi: 10.1093/infdis/jiy056. Summary RSV infection epidemiology has been the subject of many studies. As novel RSV therapeutics are reaching the final stages of …
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Strong Association of RSV and HMPV with Lower Respiratory Symptoms
Sarna M, Lambert SB, Sloots TP, Whiley DM, Alsaleh A, Mhango L, Bialasiewicz S, Wang D, Nissen MD, Grimwood K, Ware RS. Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort, Thorax, 2017 Dec 15, in press. Available from: doi: 10.1136/thoraxjnl-2017-210233. Summary Disease-pathogen associations of respiratory viruses were described in …
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How To Hold Neutrophils In Check
Geerdink RJ, Hennus MP, Westerlaken GHA, Abrahams AC, Albers KI, Walk J, Wesselink E, Janssen R, Bont L, Meyaard L. LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis, Journal of Allergy and Clinical Immunology, 2017 Oct 16, in press. Available from: doi: 10.1016/j.jaci.2017.08.031. Summary During RSV bronchiolitis neutrophils are the most abundant immune cells …
The Impact Of PCV On Bacterial / Viral Pneumonia
Fathima P, Blyth CC, Lehmann D, Lim FJ, Abdalla T, de Klerk N, Moore HC. The impact of pneumococcal vaccination on bacterial and viral pneumonia in Western Australian children: record linkage cohort study of 469,589 births (1996-2012). Clinical Infectious Diseases, 2017 Oct 23, in press. Available from: doi: 10.1093/cid/cix923. Summary A record linkage cohort study …
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Pre-F-Stabilized RSV Vaccine, A New Vaccine On The Horizon?
Liu X, Liang B, Ngwuta J, Liu X, Surman S, Lingemann M, Kwong PD, Graham BS, Collins PL, Munir S. Attenuated human parainfluenza virus type 1 (HPIV1) expressing the respiratory syncytial virus (RSV) fusion F glycoprotein from an added gene: effects of pre-fusion stabilization and packaging of RSV F. Journal of Virology, November 2017, vol. …
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The first large case series of in-hospital RSV deaths
Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sanchez JF, O’Brien KL, on behalf of the PERCH Study Group, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Rosane Pires …
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C-reactive protein differentiates RSV from bacterial infection
Higdon MM, Le T, O’Brien KL, Murdoch DR, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, Scott JAG, Thea DM, Awori JO, Baillie VL, Cascio S, Chuananon S, DeLuca AN, Driscoll AJ, Ebruke BE, Endtz HP, Kaewpan A, Kahn G, Karani A, Karron RA, Moore DP, Park …
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