Paper of the Month

RESCEU Publications

Paper of the Month

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Risk of childhood wheeze and asthma after respiratory syncytial virus infection in full‐term infants

Asuncion Mejias, Bingcao Wu, Neeta Tandon, Wing Chow, Ram Varma, Eduardo Franco, Octavio Ramilo Summary Most studies that have looked at the relationship between RSV and further respiratory sequelae such as asthma and wheeze have been performed in premature infants, or infants with other risk factors, as a result few studies have been conducted on …

Low resistance against a novel highly potent site IV antibody

Tang A, Chen Z, Cox KS, Su HP, Callahan C, Fridman A, Zhang L, Patel SB, Cejas PJ, Swoyer R, Touch S, Citron MP, Govindarajan D, Luo B, Eddins M, Reid JC, Soisson SM, Galli J, Wang D, Wen Z, Heidecker GJ, Casimiro DR, DiStefano DJ, Vora KA. Summary RB1 is a humanized monoclonal antibody that binds to site IV of the RSV F glycoprotein and is 50 times more potent than palivizumab. Tang and colleagues describe the …

Respiratory syncytial virus infection among adults during influenza season: A frequently overlooked diagnosis

Javier Martínez‐Sanz, Sergio Gilaberte Reyzábal, Juan Salillas, María Rosa Lago Gómez, M. Elena Rodríguez‐Zurita, Miguel Torralba Summary Many epidemiological studies of RSV have observed a sharp drop off of RSV infections with the coming of influenza season in late December and early January. Whether or not RSV incidence falls off with the influx of influenza …

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, Moore DP, Nunes M, Rath B, Campbell H, Nair H; RSV Global Epidemiology Network; RESCEU investigators. Summary The relationships between the  seasonalities of RSV, Influenza Virus and Parainfluenza virus remain poorly understood, and a robust predictive model for epidemics has not yet been developed in the case of RSV. While the consistent and predictable temporal relationship between …

DS-Cav1 beats previous subunit RSV vaccines

Crank MC, Ruckwardt TJ, Chen M, Morabito1 KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT,  Schwartz RM, Kueltzo1 L, Cooper JW, Chen P, Stein JA, Carlton1 K, Gall JG, Nason MC, Kwong PD, Chen1 GL, Mascola JR,McLellan JS, Ledgerwood JE, Graham BS, …

Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses

Lam TT, Tang JW, Lai FY, Zaraket H, Dbaibo G, Bialasiewicz S, Tozer S, Heraud JM, Drews SJ, Hachette T, Chan PK, Koay ES, Lee HK, Tee KK, Liu Y, Fraaij P, Jennings L, Waris M, Krajden M, Corriveau A, Jalal H, Nishimura H, Nymadawa P, Badarch D, Watanabe A, Kabanda A, Sloots T, Kok J, Dwyer DE, Koopmans M, INSPIRE (International Network for the Sequencing of Respiratory Viruses). Summary The results of a large trial monitoring the incidence of a range of respiratory viruses across 18 …

RSV and the microbiome

Alejandro Diaz-Diaz, Cristina Garcia-Maurino, Alejandro Jordan-Villegas, Jeffrey Naples,  Octavio Ramilo and Asuncion Mejias Summary Antimicrobial resistance (AMR) is one of the biggest threats to mankind. It is related to massive use of antibiotics for bacterial infection, in particular respiratory infections. Antibiotics are also used, often unnecessary in case of respiratory viral infections, including RSV infection. However, recent studies suggest …

Incidence of Respiratory Syncytial Virus Bronchiolitis in Hospitalized Infants Born at 33-36 Weeks Gestational Age Compared with those Born at Term: A Retrospective Cohort Study

Greenberg D, Dagan R, Shany E, Ben-Shimol S, Givon-Lavi N. Summary A retrospective cohort study conducted in Soroka, Israel that compared the incidence rates of RSV Bronchiolitis among pre term (33-36 weeks gestational age) children, and those born at term. Rate of bronchiolitis in the general population were extrapolated from the numbers collected in hospital. …

A do-it-yourself toolbox to make an RSV vaccine.

Jessica Marcandalli, Brooke Fiala, Sebastian Ols, …, Karin Lore´ , Laurent Perez, Neil P. King Summary Self-assembling proteins are promising inducers of a strong antibody response, because they enable multivalent antigen presentation. Jessica Marcandalli and colleagues designed such a self-assembling protein nanoparticle vaccine, based on prefusion-stabilized RSV-F antigen. It is a computational vaccine that consists …

Respiratory syncytial virus-associated hospitalisations in Australia, 2006-2015.

Saravanos GL, Sheel M, Homaira N, Dey A, Brown E, Wang H, Macartney K, Wood NJ. Summary Saravanos et al provide a long term and comprehensive study of Respiratory Syncytial Virus infection in Australia. This study aimed to estimate hospitalisation rates across the whole Australian population, while paying attention to factors that may influence this, …

The repertoire of maternal anti-viral antibodies in human newborns.

Pou C, Nkulikiyimfura D, Henckel E, Olin A, Lakshmikanth T, Mikes J, Wang J, Chen Y, Bernardsson AK, Gustafsson A, Bohlin K, Brodin P. Summary Virscan is a novel diagnostic tool to measure antibodies against >1000 viral strains. It shows previous viral exposures of an individual person. Christian Pou and colleagues used Virscan to get …

Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

Ting Shi, Angeline Denouel, Anna K. Tietjen, Iain Campbell, Emily Moran, Xue Li, Harry Campbell, Clarisse Demont, Bryan O. Nyawanda, Helen Y. Chu, Sonia K. Stoszek, Anand Krishnan, Peter Openshaw, Ann R. Falsey, and Harish Nair, for the RESCEU Investigators Summary Shi and colleagues conducted a systemtic review and meta analysis of the global burden …

The endangered future of Syngem, a novel bacterium-like particle based, needle-free, RSV vaccine

Ascough S, Vlachantoni I, Kalyan M, Haijema BJ, Wallin- Weber S, Dijkstra-Tiekstra M, Ahmed MS, Roosmalen M van, Grimaldi R, Zhang Q, Leenhouts K, Openshaw PJ and Chiu C. Summary Despite numerous years of research we are still lacking a safe and effective RSV vaccine. This process is hindered by numerous problems: the lack of a correlate …

High incidence of RSV illness in Malian infants, primarily caused by RSV-B

Andrea G. Buchwald, Boubou Tamboura, Sharon M. Tennant, Fadima C. Haidara, Flanon Coulibaly, Moussa Doumbia, Fatoumata Diallo, Adama M. Keita, Samba O. Sow, Karen L. Kotloff, Myron M. Levine, Milagritos D. Tapia. Summary Buchwald and colleagues conducted an active community-based surveillance for RSV infection in Mali. 1871 infants were followed from birth to six months …

Respiratory syncytial virus and influenza hospitalisations by HIV status in South African children

Meredith L. McMorrow, Stefano Tempia, Sibongile Walaza, Florette K. Treurnicht, Jocelyn Moyes, Adam L. Cohen, Marthi Pretorius, Orienka Hellferscee, Nicole Wolter, Anne von Gottberg, Arthemon Nguweneza, Johanna M. McAnerney, Fathima Naby, Omphile Mekgoe, Marietjie Venter, Shabir A. Madhi, and Cheryl Cohen. The Role of Human Immunodeficiency Virus in Influenza- and Respiratory Syncytial Virus–associated Hospitalizations in …

Sample size required to detect the effect of RSV vaccination on recurrent wheezing

Riddell CA, Bhat N, Bont LJ, Dupont WD, Feikin DR, Fell DB, Gebretsadik T, Hartert TV, Hutcheon JA, Karron RA, Nair H, Reiner RC Jr, Shi T, Sly PD, Stein RT, Wu P, Zar HJ, Ortiz JR; WHO Technical Working Group on Respiratory Syncytial Virus Vaccination During Pregnancy to Prevent Recurrent Childhood Wheezing.Vaccine. 2018 Dec 18;36(52):8100-8109. doi: 10.1016/j.vaccine.2018.10.041. Epub 2018 Nov 22. Informing randomized clinical trials of respiratory syncytial virus vaccination during pregnancyto prevent recurrent childhood wheezing: A sample size analysis. Summary Riddell and colleagues investigated the feasibility of utilizing maternal RSV vaccine trials to detect the effect of RSV vaccine on …

Miniature lungs: the road towards a better model to study RSV disease

Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans …

Morbidity and mortality in older adults with RSV vs. influenza infection

Bradley Ackerson, Hung Fu Tseng, Lina S. Sy, Zendi Solano, Jeff Slezak, Yi Luo, Christine A. Fischetti, Vivek Shinde in Clin Infect Dis. 2018 Nov 19. doi: 10.1093/cid/ciy991. [Epub ahead of print] Severe Morbidity And Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection In Hospitalized Older Adults Summary A large cohort of adults >=60 …

Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

Kempaiah Rayavara, Alexander Kurosky, Susan J. Stafford, Nisha J. Garg,Allan R. Brasier, Roberto P. Garofalo, and Yashoda M. Hosakote, J Immunol 2018; 201:2753-2766; Prepublished online 1 October 2018; http://www.jimmunol.org/content/201/9/2753 doi: 10.4049/jimmunol.1800558 Summary The first epithelial molecular events upon infection define the size and direction of the inflammatory response, which ultimately defines disease in RSV infected …

Patterns of respiratory pathogen circulation in rural coastal Kenya

Munywoki PK, Koech DC, Agoti CN, Cane PA, Medley GF, Nokes DJ. Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya. Clin Infect Dis. 2018 Oct 30;67(10):1559-1567. doi: 10.1093/cid/ciy313. Summary A household-based active surveillance during RSV season was conducted in 47 households in Kilifi Kenya. This study showed that 93.4% of the study participants had at least 1 virus detected. Adenovirus (AdV), human coronavirus (HCoV) and rhinovirus …

The significance of Human Respiratory Syncytial Virus (HRSV) in children from Ghana with acute lower respiratory tract infection: a molecular epidemiology analysis

Obodai E, Odoom JK, Adiku T, Goka B, Wolff T, Biere B, Schweiger B, Reiche J. The significance of human respiratory syncytial virus (HRSV) in children from Ghana with acute lower respiratory tract infection: A molecular epidemiological analysis, 2006 and 2013-2014. PLoS One. 2018 Sep 10;13(9):e0203788. doi: 10.1371/journal.pone.0203788. eCollection 2018. Summary The molecular epidemiology of RSV infection is increasingly thought to be essential …

Implications of viral genomic variability for RSV immunisation programs

Vicente Mas, Nair H, Campbell H, Melero JA, Williams TC. Antigenic and sequence variability of the human respiratory syncytial virus F glycoproteincompared to related viruses in a comprehensive dataset. Vaccine. 2018 Oct 3. pii: S0264-410X(18)31325-2. doi: 10.1016/j.vaccine.2018.09.056; in press. Summary In this study Williams and colleagues examined variability in the RSV F glycoprotein from published data virus strains sequenced in different locations worldwide. Looking at the specific parts of the protein targeted …

Respiratory viral epidemiology in rural Kenya

Nyiro JU, Munywoki P, Kamau E, Agoti C, Gichuki A, Etyang T, Otieno G, Nokes DJ. Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baselineepidemiological observations. Wellcome Open Res. 2018 Jul 25;3:89. doi: 10.12688/wellcomeopenres.14662.1. eCollection 2018. Summary This paper reports the epidemiological data of respiratory viruses at nine outpatient health facilities in rural coastal Kenya as well as in hospital settings. More than half (53.7%) of participants with ARI symptoms were from children …

New insights into aetiology of neonatal infections

Saha SK, Schrag SJ, El Arifeen S, Mullany LC, Shahidul Islam M, Shang N, Qazi SA, Zaidi AKM, Bhutta ZA, Bose A, Panigrahi P, Soofi SB, Connor NE, Mitra DK, Isaac R, Winchell JM, Arvay ML, Islam M, Shafiq Y, Nisar I, Baloch B, Kabir F, Ali M, Diaz MH, Satpathy R, Nanda P, Padhi BK, Parida S, Hotwani A, Hasanuzzaman M, Ahmed S, Belal Hossain M, Ariff S, Ahmed I, Ibne Moin SM, Mahmud A, Waller JL, Rafiqullah I, Quaiyum MA, Begum N, Balaji V, Halen J, Nawshad Uddin Ahmed ASM, Weber MW, Hamer DH, Hibberd PL, Sadeq-Ur Rahman Q, Mogan …

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh …

RSV burden in HIV-infected mothers

Madhi SA, Cutland CL, Downs S, Jones S, van Niekerk N, Simoes EAF, Nunes MC.Burden of Respiratory Syncytial Virus Infection in South African Human Immunodeficiency Virus(HIV)-Infected and HIV Uninfected Pregnant and Postpartum Women: A Longitudinal Cohort Study. Clin InfectDis. 2018 May 17;66(11):1658-1665. Available from: doi: 10.1093/cid/cix1088. Summary A longitudinal cohort study from South Africa investigated the RSV burden in HIV-infected and HIV-uninfected women (from mid-pregnancy until 24 weeks of postpartum). The incidence of RSV illness in 2011 among HIV-infected women was …

Epidemiology of respiratory virus infection in preterm infants in a tropical area

Yeo KT, de la Puerta R, Tee NWS, Thoon KC, Rajadurai VS, Yung CF. Burden, etiology and risk factors of respiratory virus infections among symptomatic preterminfants in the tropics: a retrospective single-center cohort study. Clin Infect Dis. 2018 Apr 12, in press. Available from: doi: 10.1093/cid/ciy311 Summary A 11-year retrospective cohort data linkage study was performed in one hospital from Singapore to investigate the epidemiology of respiratory viral infections (RVIs). This study included 1854 preterm infants (born with ≤32 weeks of gestational age) admitted with laboratory confirmed RVIs before 2 years …

Subcutaneous treatment with diabetes drug liraglutide (Victoza®) is effective treatment of RSV infection

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV2, Niswender KD, Peebles RS Jr. Glucagon-like peptide-1 receptor signaling attenuates RSV-induced type 2 responses and immunopathology. J Allergy Clin Immunol. 2018 Apr 17,in press. Available from: pii: S0091-6749(18)30561-X. doi: 10.1016/j.jaci.2018.01.053. Summary The glucagon-like peptide(GLP)-1 receptor agonist liraglutide has the potential to be an effective treatment of RSV bronchiolitis. This …

RSV during infancy and childhood asthma: the puzzle remains

Scheltema NM, Nibbelke EE, Pouw J, Blanken MO, Rovers MM, Naaktgeboren CA, Mazur NI, Wildenbeest JG, van der Ent CK, Bont LJ. Respiratory syncytial virus prevention and asthma in healthy preterm infants: a randomised controlled trial. Lancet Respir Med. 2018 Feb 27; in press. Available from: doi: 10.1016/S2213-2600(18)30055-9. Summary A 6-year single-blind, randomised, placebo-controlled trial (MAKI) was carried out to evaluate the effect of RSV prevention during infancy on asthma and lung function at …

RSV Hospitalisation: Preterm Infants with CLD Compared to Term Infants

Winterstein AG, Choi Y, Meissner HC. Association of Age With Risk of Hospitalization for Respiratory Syncytial Virus in Preterm Infants With Chronic Lung Disease, JAMA Pediatr. 2018 Feb 1;172(2):154-160, in press. Available from: doi: 10.1001/jamapediatrics.2017.3792. Summary American Academy of Pediatrics guidelines recommends RSV prophylaxis with palivizumab up to 24 months age for infants with chronic lung disease (CLD). Winterstein and colleagues conducted a …

Respiratory Syncytial Virus Seasonality: A Global Overview

Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, Rodríguez-Tenreiro C, Sly P, Ramilo O, Mejías A, Baraldi E, Papadopoulos NG, Nair H, Nunes MC, Kragten-Tabatabaie L, Heikkinen T, Greenough A, Stein RT, Manzoni P, Bont L, Martinón-Torres F, ReSViNET. Respiratory Syncytial Virus Seasonality: A Global Overview, J Infect Dis. 2018 Jan 30, in press. Available from: doi: 10.1093/infdis/jiy056. Summary RSV infection epidemiology has been the subject of many studies. As novel RSV therapeutics are reaching the final stages of …

Strong Association of RSV and HMPV with Lower Respiratory Symptoms

Sarna M, Lambert SB, Sloots TP, Whiley DM, Alsaleh A, Mhango L, Bialasiewicz S, Wang D, Nissen MD, Grimwood K, Ware RS. Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort, Thorax, 2017 Dec 15, in press. Available from: doi: 10.1136/thoraxjnl-2017-210233. Summary Disease-pathogen associations of respiratory viruses were described in …

How To Hold Neutrophils In Check

Geerdink RJ, Hennus MP, Westerlaken GHA, Abrahams AC, Albers KI, Walk J, Wesselink E, Janssen R, Bont L, Meyaard L. LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis, Journal of Allergy and Clinical Immunology, 2017 Oct 16, in press. Available from: doi: 10.1016/j.jaci.2017.08.031. Summary During RSV bronchiolitis neutrophils are the most abundant immune cells …

The Impact Of PCV On Bacterial / Viral Pneumonia

Fathima P, Blyth CC, Lehmann D, Lim FJ, Abdalla T, de Klerk N, Moore HC. The impact of pneumococcal vaccination on bacterial and viral pneumonia in Western Australian children: record linkage cohort study of 469,589 births (1996-2012). Clinical Infectious Diseases, 2017 Oct 23, in press. Available from: doi: 10.1093/cid/cix923. Summary A record linkage cohort study …

Pre-F-Stabilized RSV Vaccine, A New Vaccine On The Horizon?

Liu X, Liang B, Ngwuta J, Liu X, Surman S, Lingemann M, Kwong PD, Graham BS, Collins PL, Munir S. Attenuated human parainfluenza virus type 1 (HPIV1) expressing the respiratory syncytial virus (RSV) fusion F glycoprotein from an added gene: effects of pre-fusion stabilization and packaging of RSV F. Journal of Virology, November 2017, vol. …

The first large case series of in-hospital RSV deaths

Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sanchez JF, O’Brien KL, on behalf of the PERCH Study Group, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Rosane Pires …

C-reactive protein differentiates RSV from bacterial infection

Higdon MM, Le T, O’Brien KL, Murdoch DR, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, Scott JAG, Thea DM, Awori JO, Baillie VL, Cascio S, Chuananon S, DeLuca AN, Driscoll AJ, Ebruke BE, Endtz HP, Kaewpan A, Kahn G, Karani A, Karron RA, Moore DP, Park …